Fig. 9. Applications of CRISPR/Cas9 technology (please see details in the text).Fig. 8. Some of new approaches to generate genetically modified mice. A. FLP/FRT or Cre/LoxP site-directed recombination systems have been used to generate conditional knockout mutations. B. Direct transplantation of rAAV particles into the oviduct of pregnant females to generate knockout mice.Fig. 9. Applications of CRISPR/Cas9 technology.